Lona Louring Christrup

Lona Louring Christrup

Professor emerita

Education & Degrees:

  • M.Sc. (Pharm): The Royal Danish School of Pharmacy, 1978-1986           
  • Ph.D.  The Royal Danish School of Pharmacy 1983-1986.

Former employment: (Current PharmaSchool)

  • Assistant professor 1986-1990
  • Associate professor 1990-2010

Research Abroad:

Dept. of Clinical Pharmacolo­gy, University of Adelaide, Australia. 1994 -1997

Dept. of Pharmaceuti­cal Sci­ence, Univer­sity of Notting­ham, Eng­land. 1988

Current Affiliations/Memberships

  • EFIC (European Federation of IASP (International Association for the Study of Pain) Chapters) Task for Appropriate use of Opioids: 2014-
  • Nordic OIC&OIBD (opioid induced constipation & opioid induced bowel dysfunction) Consensus Working Group: 2014-
  • EFIC Task for Reimbursement Policies of Opioid Analgesics: 2011- (Chair)
  • Steering committee for the MULTIPAIN research consort: 2011-
  • Editorial board of European Journal of Hospital Pharmacy 2008- 

Scientific Work

Publications: 131 research papers, 26 dissemination papers (popular scientific, debate, etc.), 2 patent applications (1 patent granted) and 1 thesis, 1 expert report and editor of 1 book. Reviewer for more than 20 scientific journals Participation in more than 160 scientific meetings and conferences, presentation of more than 90 poster or free oral presentations and more than 40 invited lectures. 
Current research activities are focused on: 

  • Influence of administration routes and delivery systems on the pharmacokinetic and pharmacodynamic behaviour of opioids with special focus on the dose-response of both wanted and unwanted effects. 
  • PK/PD modeling of the effects of opioids. 
  • Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs.
  • MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models.
  • Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs. 
  • MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models. 

Supervisor Responsibilities and Teaching

Supervisor for a total of 26 Ph.D. students (currently 4), 8 pre graduate scholar students and more than 200 master students.  Member of the assessment committees for 13 PhD. theses.

Educational activities have included a broad spectrum of pharmaceutical disciplines, such a pharmaceutical technology, biopharmaceutics, drug delivery/formulation, pharmacotherapy, clinical pharmacy, social pharmacy, and pharmacology at both pre graduate and post-graduate level.

Activities have included lectures, laboratory exercises, work-shops, tutorials, supervision as well as  examnination, evaluation and course planning and managing.

Udvalgte publikationer

  1. Udgivet

    Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study

    Kurita, Geana Paula, Tange, U. B., Farholt, H., Sonne, N. M., Strömgren, A. S., Ankersen, L., Kristensen, L., Bendixen, L., Grønvold, Mogens, Petersen, M. A., Nordly, M., Christrup, Lona Louring, Niemann, C. & Sjøgren, P., 22 jan. 2013, I: Acta Anaesthesiologica Scandinavica. 57, s. 518-525

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  2. Udgivet

    Pharmacokinetic/pharmacodynamic relationships of tranddermal buprenorphine and fentanyl in experimental human pain models

    Andresen, T., Upton, R. N., Foster, D. J. R., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., apr. 2011, I: Basic & Clinical Pharmacology & Toxicology. 108, 4, s. 274-284

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  3. Udgivet

    Symptoms and side effects in chronic non-cancer pain:patient report vs. systematic assessment

    Jonsson, T., Christrup, Lona Louring, Højsted, J., Villlesen, H. H., Albjerg, T., Ravn-Nielsen, L. V. & Sjøgren, P., 2011, I: Acta Anaesthesiologica Scandinavica. 55

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  4. Udgivet

    Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners

    Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2010, I: Journal of Opioid Management. 6, 4, s. 259-68 9 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  5. Udgivet

    The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:  a randomized controlled trial

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2010, I: Journal of Hypertension. 28, 1, s. 194-200

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  6. Udgivet

    A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

    Olesen, A. E., Upton, R., Staahl, C., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2010, I: Clinical Pharmacokinetics. 49, 12, s. 817-827

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  7. Udgivet

    The importance of the proper procedures in the implementation process of new guidelines

    Villesen, H. H., Faber, T., Skov, B., Bonde, J. & Christrup, Lona Louring, 2010, I: E J H P Practice. 16, 3

    Publikation: Bidrag til tidsskriftTidsskriftartikel

  8. Udgivet

    The Danish Barriers Questionnaire-II: preliminary validation in cancer pain patients

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, I: Pain Practice. 9, 4, s. 266-74 8 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  9. Udgivet

    Barries to cancer management: a review of empirical research

    Jacobsen, R., Liubarskiene, Z., Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Samsanaviciene, J., 2009, I: Medicina. 45, 6, s. 427-432

    Publikation: Bidrag til tidsskriftReview

  10. Udgivet

    Translational pain research: evaluating analgesic effect in experimental visceral pain models

    Olesen, A. E., Andresen, T., Christrup, Lona Louring & Upton, R. N., 2009, I: World Journal of Gastroenterology. 15, 2, s. 177-81

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  11. Udgivet

    Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2009, I: Blood Pressure. 18, 5, s. 280-285

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  12. Udgivet

    Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study

    Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2009, I: Pain Medicine. 10, 8, s. 1442-1451

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  13. Udgivet

    The Danish version of the questionnaire on pain communication: preliminary validation in cancer patients: preliminary validation in cancer patients

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, I: Acta Anaesthesiologica Scandinavica. 53, 6, s. 807-15 8 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  14. Udgivet

    The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients: preliminary validation in cancer pain patients

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, I: Pain Practice. 9, 1, s. 1-7 6 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  15. Udgivet

    Role of active metabolites in the use of opioids

    Coller, J. K., Christrup, Lona Louring & Somogyi, A. A., 2009, I: European Journal of Clinical Pharmacology. 65, 2, s. 121-139

    Publikation: Bidrag til tidsskriftReview

  16. Udgivet

    Patient-related barriers to cancer pain management: a systematic exploratory review: a systematic exploratory review

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring & Sjøgren, P., 2009, I: Scandinavian Journal of Caring Sciences. 23, 1, s. 190-208 18 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  17. Udgivet

    Novel formulations and routes of administration fro opioids in the treatment of breakthrough pain

    Christrup, Lona Louring, Lundorff, L. & Werner, M., 2009, I: Therapy. 6, 5

    Publikation: Bidrag til tidsskriftTidsskriftartikel

  18. Udgivet

    Generisk substitution af depotpraeparater indeholdende opioider

    Christrup, Lona Louring, Jensen, N., Jonsson, T., Kristensen, H. G., Sjøgren, P. & Steffansen, B., 4 maj 2009, I: Ugeskrift for læger. 171, 19, s. 1624; author reply 1624

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  19. Udgivet

    Laegemiddelstyrelsen bør genoverveje tilladelsen til generisk substitution mellem fentanyldepotplastre

    Christrup, Lona Louring, Jensen, N., Jonsson, T., Sjøgren, P. & Steffansen, B., 2009, I: Ugeskrift for læger. 171, 44, s. 3215

    Publikation: Bidrag til tidsskriftKommentar/debat

  20. Udgivet

    Duplik til debatoplæg

    Christrup, Lona Louring, Jørgensen, N., Jonsson, T. & Sjøgren, P., 2009, I: Ugeskrift for læger. 171, 49, s. 3637

    Publikation: Bidrag til tidsskriftKommentar/debat

  21. Udgivet

    Pharmacokinetic-Pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

    Staahl, C., Upton, R., Foster, D. J. R., Christrup, Lona Louring, Kristensen, K., Hansen, S. H., Arendt-Nielsen, L. & Drewes, A. M., 2008, I: Journal of Clinical Pharmacology. 48, 5, s. 619-631

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  22. Udgivet

    Pharmacokinetic-Pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers

    Jensen, M. L., Sjøgren, P., Upton, R. N., Foster, D. J. R., Bonde, P., Graae, C., Skram, U., Stevner, L. L. S. & Christrup, Lona Louring, 2008, I: Basic & Clinical Pharmacology & Toxicology. 103, 1, s. 94-101

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  23. Udgivet

    Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery

    Foster, D., Upton, R., Christrup, Lona Louring & Popper, L., 2008, I: Annals of Pharmacotherapy. 42, 10, s. 1380-1387

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  24. Udgivet

    Clinical rationale for administering fentanyl to cancer pain patients: two Delphi surveys of pain management experts in Denmark

    Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2008, I: Journal of Opioid Management. 4, 6, s. 383-391

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  25. Udgivet

    Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study

    Christrup, Lona Louring, Foster, D., Popper, L. D., Troen, T. & Upton, R., 2008, I: Clinical Therapeutics. 30, 3, s. 469-481

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  26. Udgivet

    Pharmakonetics of morphine and oxycodone following intravenous administration in elderly patients

    Villesen, H. H., Banning, A., Petersen, R. H., Weinelt, S., Poulsen, J. B., Hansen, S. H. & Christrup, Lona Louring, 2007, I: Therapeutics and Clinical Risk Management. 3, 5

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  27. Udgivet

    Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

    Villesen, H. H., Kristensen, K., Hansen, S. H., Jensen, N., Skram, U. & Christrup, Lona Louring, 2007, I: European Journal of Clinical Pharmacology. 63, 8, s. 761-767

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  28. Udgivet

    Patient acceptance of a tablet reminder device

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, I: Journal of Medical Marketing (Print Edition). 7, 2, s. 152-161

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  29. Udgivet

    A new intelligent tablet reminder device - do health professionals find it of therapeutic value?

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, I: Journal of Medical Marketing (Print Edition). 7, 3, s. 235-243

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  30. Udgivet

    Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder

    Olesen, A. E., Jarvig, L., Hansen, O. B., Højsted, J., von Holstein-Rathlou, Niels-Henrik, Jonsson, T., Sjøgren, P., Sonne, N. M., Sørensen, J. T. & Christrup, Lona Louring, 2007, I: Ugeskrift for læger. 169, 21, s. 2024-9

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  31. Udgivet

    Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

    Staahl, C., Dimcevski, G., Andersen, S. D., Thorsgaard, N., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2007, I: Scandinavian Journal of Gastroenterology. 42, 3, s. 383-90

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  32. Udgivet

    Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

    Jensen, M. L., Foster, D. J. R., Upton, R. N., Kristensen, K., Hansen, S. H., Jensen, N., Nielsen, B. N., Skram, U., Villesen, H. H. & Christrup, Lona Louring, 2007, I: European Journal of Clinical Pharmacology. 63, 12, s. 1153-1159

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  33. Udgivet

    Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.

    Coller, J. K., Jørgensen, Carsten, Foster, D. J. R., James, H., Gillis, D., Christrup, Lona Louring & Somogyi, A. A., 2007, I: International Journal of Clinical Pharmacology and Therapeutics. 45, 7, s. 410-7

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  34. Udgivet

    Physician-related barriers to cancer pain management with opioid analgesics: a systematic review

    Jacobsen, Ramune, Sjøgren, P., Møldrup, C. & Christrup, Lona Louring, 2007, I: Journal of Opioid Management. 3, 4, s. 207-14

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  35. Udgivet

    Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

    Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, I: European Journal of Pharmaceutical Sciences. 24, 4, s. 297-303 6 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

ID: 1301280